تأثیر عصاره گشنیز بر میزان دفع سرب در کودکان 3 تا 7 ساله

Background and Aim: Lead (Pb) poisoning is the most common occupational poisoning that may affect family members of lead workers specially their children. The most important and irreversible effect of lead poisoning in children is on the developing of central nervous system and its evolution. High cost and severe side effects of chelating agents may result in incomplete treatment of lead poisoning in some cases. The aim of the present study was to assess the effect of Coriandrum Sativum l. (Cilantro) extracts on renal lead excretion in 3-7 year old children. Materials and Methods: In this randomized, case–control clinical trial, 32 children aged 3-7 years whose parents were lead-exposed workers were randomly divided into 2 groups. The test group received Cilantro extract and the controls were given placebos for 14 days. Blood and urine lead concentrations were determined at the beginning of the study and 14 days later. Questionnaires were designed and used for data collection. The obtained data were analyzed by T-student and Paired t-test using SPSS version 11.5 Numerical data were shown as mean ± SD and P≤0.05 was taken as the significant level. Results: Mean age and weight of the children was 4.9±1.46 years and 17.32±4.74 kg respectively and 59.4% of them were males. Duration of fathers' exposure to Pb at work was 9.14±5.63 years. Blood and urine Pb concentrations and renal lead clearance of children were 163.81±57.19, 97±48.12 µg/L and .012±.009 L/day, respectively at the beginning of the study. There were no significant differences in blood (P=0.87), urine (P=0.73) Pb concentrations and renal excretion of lead (P=0.96) between the two groups. After two weeks use of Cilantro, the mean blood lead concentration decreased (P=0.006), urine lead concentration increased (P=0.038) and renal excretion of lead increased significantly (P=0.019). But similar significant changes were observed in the control group (P=0.034, 0.021 and 0.009, respectively). There were no significant differences in blood lead concentration (P=0.93), urine lead concentration (P=0.93) and renal lead clearance (P=0.77) between the two groups at the end of the study. Conclusion: According to the results of this study, it seems that Coriandrum Sativum is not effective in lead elimination. Increasing renal lead elimination in both groups of children may be due to other factors like improvement of nutrition following the necessary educations at the beginning of this study.